Multipurpose particles made easy magnetic nanoparticle + drug binding

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Article citation: Beatriz Julián-López, J. Mater. Chem., 2007, DOI: 10.1039/b615951f

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Mesoporous maghemite–organosilica microspheres: a promising route towards multifunctional platforms for smart diagnosis and therapy

Beatriz Julián-López, Cédric Boissière, Corinne Chanéac, David Grosso, Sebastien Vasseur, Sylvain Miraux, Etienne Duguet and Clément Sanchez

The World Nanotechnology Market (2006)

pub Feb 2007
see source
The report “The World Nanotechnology Market (2006)”, provides an updated and detailed overview of the Nanotechnology market worldwide. It examines the emerging trends in the industry and provides exclusive forecasts- product wise and application wise. It includes the snapshots of different players in the industry, R&D spending in various countries and studies the patents in this technology.

Key Findings

- Market Size of the Nanoelectronics totaled to US$ 1,827 Million in 2005 and is forecasted

to reach US$ 4,219 Million by the year 2010.

- Nanofood market will soar with a CAGR 30.94% from 2006 to 2010 and will attain a market

value of US$ 20.40 Billion by 2010.

- The market for textiles using Nanotechnology will cross US$ 13.6 Billion mark by 2007. By

2012, the market is expected to reach US$ 115 Billion.

- US market for Nanotech tools is projected to increase by nearly 30% per year through 2008

to US$ 900 Million, and then triple again to US$ 2.7 Billion in 2013.

- US has the largest share of global investment in Nanotechnology. The US market had a

share of 28% in 2005, followed by Japanese market with about 24% share. The western

European market also had a quarter of the market share with major investment in countries

like Germany, UK and France. Other countries like China, South Korea, Canada and

Australia held the rest of the share.

Key Issues Addressed

- Global outlook of Nanotechnology market.

- Analysis of Nanotechnology market by various products and application areas, their market

and growth prospects.

- Key drivers, growth opportunities and challenges for Nanotechnology.

- Update on the recent developments in Nanotechnology.

- Snapshots of the key players in Nanotechnology.

Key Players Analyzed

This section provides the overview about the prominent players in the field of Nanotechnology like Altair Nanotechnologies Inc., Angstorm Medica, Aspen Aerogel, Cabot Corporation, Degussa Advanced Nanomaterials, General Nanotechnology, Nanomagnetics Limited, Nanospectra Biosciences, Quantum Dot Corporation and Zyvex Corporation.

Research Methodology

Information Sources

The information on Nanotechnology has been sourced from various means like books, newspapers, trade journals and white papers, industry portals, government agencies, trade associations, by monitoring Industry news and developments and access to more than 3000 paid databases.

Analysis Method

Ratio Analysis, Historical Trend Analysis, Linear Regression Analysis using software tools, Judgmental Forecasting and Cause and Effect Analysis.

List of Figures:

Figure 2-1: Worldwide - Nanotechnology Market (in Billion $), 2005, 2010E & 2015E

Figure 2-2: Worldwide - Forecast for Nanotechnology Industry Segmentation by

Applications (%), 2015

Figure 2-3: US & Worldwide - Start-up Companies in Nanotechnology Industry (in Units), 2005

Figure 3-1: Worldwide - R&D Expenditure (%), 2005

Figure 3-2: Worldwide - Nanotechnology R&D Expenditure (in Billion US$), 2004 & 2005

Figure 3-3: Worldwide - Government Expenditure by Region (%), 2005

Figure 3-4: Worldwide - Nanotechnology Patent Trends (in Numbers), 2000-2005

Figure 3-5: Worldwide - Nanotechnology Patents by Country (%), 2003

Figure 3-6: Worldwide - Forecast for Nanomaterials Consumption (in Billion US$), 2006-2010

Figure 3-7: Worldwide - Forecast for Nanocomposite Market (in Million US$), 2006-2011

Figure 3-8: Worldwide - Nanocomposites Market by Application Area (%), 2005

Figure 3-9: Worldwide - Nanocomposites Consumption by Types (%), 2005

Figure 3-10: Worldwide - Forecast for Inorganic Nanoporous & Microporous Adsorbents

Market (in Million US$), 2006-2009

Figure 3-11: Worldwide - Forecast for Nanomagnetic Materials and Devices Market (in

Billion US$), 2006-2009

Figure 3-12: Worldwide - Nanomagnetic Products Market in Industrial Applications (in Million

US$) 2003, 2004 & 2009E

Figure 3-13: Worldwide - Forecast for Nanopatterning Market (in Million US$), 2006-2010

Figure 3-14: Worldwide - Forecast for Nanocatalysts Market (in Billion US$), 2006-2009

Figure 3-15: Worldwide - Forecast for Nanofilms Market (in Million US$), 2006-2008

Figure 3-16: Worldwide - Forecast for Nanosensor Market (in Million US$), 2006-2009

Figure 3-17: Worldwide - Nanotechnology Investment Share (%), 2005

Figure 3-18: US - Nanotechnology Funding by Source (%), 2005

Figure 3-19: US - Federal Government Direct Funding (in Million US$), 2000-2005

Figure 3-20: US - Nanotech Tools Market (in Million US$), 2002, 2008E & 2013E

Figure 3-21: Canada - Number of Research Related Staff at National Institute of

Nanotechnology (2006-200

Figure 3-22: Europe - Expenditure on Nanotechnology (in Million US$), 2005 & 2006

Figure 3-23: Europe - Public Funding (in Million US$), 2004

Figure 3-24: Europe - R&D Infrastructure by Activity (in Numbers), 2005

Figure 3-25: Asia - Government Nanotechnology Spending by Country (in Million US$), 2005

Figure 3-26: Japan - Government Budget for Nanotechnology (in Million US$), 2001-2005

Figure 3-27: Japan - Nanotechnology Funding Agencies and National Research Institutes, 2006

Figure 3-28: China - Nanotechnology Market (in Billion US$), 2005, 2010E & 2015E

Figure 3-29: Taiwan - Forecast for Nanoscience Production Value (in Billion US$), 2006-2012

Figure 3-30: Worldwide - MEMS Materials Market (in Million US$), 2005

Figure 3-31: Worldwide - Forecast for Textile Products Market using Nanotechnologies (in

Billion US$), 2007-2012

Figure 3-32: Worldwide - Forecast for Nanoelectronics Market (in Billion US$), 2007, 2011

& 2015

Figure 3-33: Worldwide - Forecast for Nanomaterials Market (in Million US$), 2006-2010

Figure 3-34: Worldwide - Forecast for Nanotools and Equipment Market Size (in Million

US$), 2006-2010

Figure 3-35: Worldwide - Market for Nanotechnology in Life-Sciences (in Million US$),

2004, 2005 & 2010E

Figure 3-36: Worldwide - Nanotechnology Market in Automotive Sector (in Million

US$), 2000-2005

Figure 3-37: Worldwide - Forecast for Nanotechnology Market in Automotive Sector (in

Billion US$), 2006-2015

Figure 3-38: Worldwide - Forecast for Nanotechnology Market for Consumer Products (in

Billion US$), 2006-2010

Figure 3-39: Worldwide - Nanofood Market (in Billion US$), 2003 & 2005

Figure 3-40: Worldwide - Forecast for Nanofood Market (in Billion US$), 2006-2010

List of Tables:

Table 3-1: Worldwide - Corporate Expenditure by Region (in Billion US$), 2005
Table 3-2: Worldwide - Nanotechnology Startup Companies, 2005
Table 3-3: Worldwide - National Policies for Nanotechnology by Country
Table 3-4: Worldwide - Nanopatterning Tool, Template and Consumable Market by

Technology (in Million US$), 2004, 2005 & 2010E
Table 3-5: US - Budget for Nanotechnology (in Million US$), 2001, 2005 & 2006
Table 3-6: US - National Nanotechnology Initiative Investments into Nanotechnology

by Component Areas (in Million US$), 2006 & 2007
Table 3-7: Canada - Nanotechnology Developments by Provinces, 2006
Table 3-8: Germany - Nanotechnology Research Centers, 2005
Table 3-9: Germany - Nanotechnology Projects Public Funding (in Million US$), 2002-2005
Table 3-10: France - Nanotechnology Developments (1999-2002 & 2005)
Table 3-11: France - Nanotechnology Research Centers, 2005
Table 3-12: Netherlands - Nanotechnology Research Centers, 2005
Table 3-13: UK - Nanotechnology Research Centers, 2005
Table 3-14: Japan - Key Nanotechnology Financers, 2006
Table 3-15: Japan - Nanobio Projects Funding by Category (in Million US$), 2005
Table 3-16: South Korea - Nanotechnology Investment Plan (in Million US$), 2001-2004,

2005-2007 & 2008-2010
Table 3-17: Application Areas for Nanomaterials
Table 3-18: Application Areas for Nanotools and Equipments
Table 4-1: Government Support for Nanotechnology (in Million £)
Table 4-2: Public Perception on Nanotechnology, 2005

An economic argument for pre-emptive U.S. nano regulations

Stratfor, a global intelligence consultancy, just released new predictions for global industry regulations, including nanotechnology. Even though their analyses severely underestimate the importance of country-specific communication and opinion environments, one aspect of their argument is well taken. Regulations in Europe or other G8 countries will directly impact regulatory efforts (or attempts to avoid regulations) in the U.S.

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World’s first nano safety label

The U.S. press is just now picking up on the story that ran about a week ago in Europe (see nanopublic posting from March 3, 2007).

8/03/2007 - A Swiss firm is offering the first process risk management and safety certification for pharma companies working with nanoparticles and technologies.
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Drug delivery system uses nanotechnology

BUFFALO, N.Y., March 8 U.S. scientists have developed an unusual nano-centered drug delivery system in which the drug itself acts as the delivery vehicle.
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2nd Nanotoxicology Conference

Apr 19, 2007 - Apr 21, 2007
San Servolo, Venice, Veneto Italy
[Italy]
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Robotic age poses ethical dilemma

An ethical code to prevent humans abusing robots, and vice versa, is being drawn up by South Korea.
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Cheap Nano Solar Cells

Monday, March 05, 2007
Carbon nanotubes could help make nanoparticle-based solar cells more efficient and practical.
By Kevin Bullis
Researchers at University of Notre Dame, in Indiana, have demonstrated a way to significantly improve the efficiency of solar cells made using low-cost, readily available materials, including a chemical commonly used in paints. The researchers added single-walled carbon nanotubes to a film made of titanium-dioxide nanoparticles, doubling the efficiency of converting ultraviolet light into electrons when compared with the performance of the nanoparticles alone. The solar cells could be used to make hydrogen for fuel cells directly from water or for producing electricity. Titanium oxide is a main ingredient in white paint.
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PROBE TO DETECT SPREAD OF BREAST CANCER CO-DEVELOPED BY UH SCIENTIST

Office of External Communications

Houston, TX 77204-5017 Fax: 713.743.8199

FOR IMMEDIATE RELEASE
March 5, 2007

Contact: Lisa Merkl
713.743.8192 (office)
713.605.1757 (pager)
lkmerkl@uh.edu

NOTE TO JOURNALISTS: A photo of a demo of this procedure for staging and treating breast cancer is available on the Web at http://www.uh.edu/admin/media/nr/2007/02feb/abrazdeikisph.html.

PROBE TO DETECT SPREAD OF BREAST CANCER CO-DEVELOPED BY UH SCIENTIST
Device to Locate Magnetic Nanoparticles in Lymph Nodes

HOUSTON, March 5, 2007 – High-temperature superconductors hold the key to a handheld tool for surgeons that promises to be more accurate, cost-effective and safer than existing methods for staging and treating various cancers, including breast cancer.

Audrius Brazdeikis, research assistant professor of physics in the College of Natural Sciences and Mathematics at the University of Houston, and Quentin Pankhurst, a professor of physics from the University College of London (UCL), have developed a novel detection procedure combining nanotechnology and advanced magnetic sensing based on high-temperature superconductors. Their innovation will enable surgeons to more effectively locate the sentinel lymph node – the first lymph node to which a tumor’s metastasizing cancer cells will drain.

The researchers produced an ultrasensitive magnetic probe to detect minuscule magnetic fields in the body. The probe is a supersensitive magnetometer – an instrument used to track the presence of clinically introduced magnetic nanoparticles. During breast cancer surgery, a surgeon will inject a magnetic nanoparticle dye, already approved as an imaging contrast agent by the Food and Drug Administration, into the tumor or into tissues surrounding the tumor.

Receiving a $250,000 grant to be used from 2004 to 2006 from the United Kingdom Department of Trade and Industry under the UK-Texas Bioscience Collaboration Initiative, Brazdeikis and Pankhurst were required to show “proof of concept” by building a device and showing it worked. An ethics committee in the UK since has approved the detection procedure for a clinical trial of women undergoing breast cancer surgery at University College Hospital, London.

Dr. Michael Douek, a London surgeon who specializes in breast surgery and is a senior lecturer at UCL, is overseeing the trial and used the probe for the first time in surgery in December. Douek, who visited Houston recently in preparation for the testing, said that the ethics committee gave the hospital permission to use the probe in 10 surgeries and that after a review of those procedures, the number could increase to 100.

“We expect to start new clinical trials in Japan and Europe before the end of 2007,” Brazdeikis said. “Our technology will be extensively validated by different surgeons in various countries.”

Brazdeikis, who heads the Biomedical Imaging Group at the Texas Center for Superconductivity at UH (TcSUH), said a goal of the grant was to commercialize biomedical technology developed at universities through collaborative research. He and Pankhurst, deputy director of the London Centre for Nanotechnology, have formed a medical devices company – Endomagnetics Inc. – to bring their technology to the marketplace and patented the probe.

“The company plans to roll out the production of the technology in 2008,” Brazdeikis said. “We hope that in the next two to three years practice assisted with our new probe will become more widely adopted by surgeons.”

Endomagnetics also already has garnered recognition from such key world figures as England’s Prince Andrew, his country’s special representative for international trade and investment, who highlighted new technology developed by the nanotechnology industry at the Nano-TX ’06 conference in Dallas. He cited the UH-UCL collaboration and Endomagnetics’ as an “exciting example of the early stages of this kind of progress.”

“The partnership has resulted in a technology used to locate lymph nodes for the staging and treatment of various forms of cancer, including breast cancers and melanomas, and some of the more disfiguring and demoralizing forms of cancer,” he said, according to a transcript of his remarks.

“Although the technology has potential for use in the staging and treatment of other cancers, including lung and prostate cancer, the instrument needs to be customized for the type of surgery,” said Douek, who has advised the researchers from the beginning of the probe’s development. “We went through a whole series of different probes during the course of a year. I was interested in being part of the project because of my interest in magnetic resonance imaging. This is an extension of that technology.”

A surgeon holds the probe, which incorporates two sets of coils connected to a sensor. One set of coils magnetizes the magnetic particles, and the second detects the magnetic response from those particles. The sensor, known as an HTS SQUID (or high-temperature superconducting quantum interference device) is located in a cryogenic vessel on a cart and is submerged in liquid nitrogen that cools the sensor to 77 K, equivalent to -320.5 F. The system uses custom-built electronics and software on a laptop computer to give the surgeon visual and audio feedback while tracking the magnetic nanoparticles in the body.

“When breast cancer is diagnosed, and a tumor has been located, a critically important issue is whether the cancer has spread to other parts of the body – a process that occurs via the transport of metastatic cancer cells through the lymphatic system,” Brazdeikis said. “The surgeon looks for lymph nodes close to the cancer. They are not easy to find. The probe is a tool for the surgeon to use during the surgery to locate the sentinel lymph node.”

Existing practice calls for a breast cancer patient to receive two preoperative injections – a radioactive isotope and a blue dye – eight to 12 hours before surgery, frequently requiring hospitalization the night before the operation. Later, in the operating room, the surgeon uses a handheld gamma probe, aided by the visual observation of the dye, to locate the lymph node with the highest radioactivity.

“Surgeons have a very small window of opportunity to locate the lymphatic nodes that the cancer drains into,” Brazdeikis said. “Our technology offers unprecedented quality and value of care benefits to patients, doctors and hospital administrators over existing procedures.”

The UH-UCL technology allows a surgeon to administer one injection – the magnetic dye that takes only 10 to 15 minutes to work – and eliminates the need for a nuclear medicine practitioner to inject the radioactive material. A patient thus may not have to be hospitalized while waiting, and the technology eliminates unnecessary patient and surgeon exposure to radioactivity.

“We introduce a paradigm-shifting new technology for the staging and treatment of breast and other forms of cancer,” Brazdeikis said. “It will be very appealing for surgeons to take this technology into their practice.”

About the University of Houston
The University of Houston, Texas’ premier metropolitan research and teaching institution, is home to more than 40 research centers and institutes and sponsors more than 300 partnerships with corporate, civic and governmental entities. UH, the most diverse research university in the country, stands at the forefront of education, research and service with more than 35,000 students.

About the College of Natural Sciences and Mathematics
The UH College of Natural Sciences and Mathematics, with nearly 400 faculty members and approximately 4,000 students, offers bachelor’s, master’s and doctoral degrees in the natural sciences, computational sciences and mathematics. Faculty members in the departments of biology and biochemistry, chemistry, computer science, geosciences, mathematics and physics have internationally recognized collaborative research programs in association with UH interdisciplinary research centers, Texas Medical Center institutions and national laboratories.

To receive UH science news via e-mail, visit www.uh.edu/admin/media/sciencelist.html.

For more information about UH visit the university’s ‘Newsroom’ at www.uh.edu/admin/media/newsroom.

another nanofood article

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NanoRisk Framework from Environmental Defense and DuPont

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The Cultural Cognition Project at Yale Law School in the U.S

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Nanotechnology and the Pentagon’s 21st century military visions

Nanowerk News) Last Wednesday, a new report came out from the U.S. Department of Defense (DoD), dryly titled “Defense Science Board 2006 Summer Study on 21st Century Strategic Technology Vectors” (pdf download, 1.1 MB).
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Nanotech could revolutionise global healthcare

Nanotechnology has the potential to generate “enormous” health benefits for the more than five billion people living in the developing world, according to a leading professor of medicine.
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My comment: Its much too simple as its outlined in the article more drugs more technology do not good as such if the societal framework (not just related to businesses) is changed. But that does not just mean to direct more tech research priorities towards the needs of the poor. It also means to look at whether new research is actually needed and whether existing tech and sciences can deal with the problem. We have today drugs sciences and technologies who do not reach the people in need. Further more often social changes are much more effective in fighting diseases and preventing the increase of people with a given disease and to make the lives of the poor better than just producing more drugs or technologies.

To slow the progress of Parkinson’s disease, doctors planted electrodes deep in my brain. Then they turned on the juice.

from wired more at source

Nanoparticle Research Offers Hope of Artificial Retinas, Prostheses

Here’s how nano research might pave the way to the development of artificial retinas based on photosensitive nanoparticles:

The world’s first direct electrical link between nerve cells and photovoltaic nanoparticle films has been achieved by researchers at the University of Texas Medical Branch at Galveston (UTMB) and the University of Michigan. The development opens the door to applying the unique properties of nanoparticles to a wide variety of light-stimulated nerve-signaling devices — including the possible development of a nanoparticle-based artificial retina.

Nanoparticles are artificially created bits of matter not much bigger than individual atoms. Their behavior is controlled by the same forces that shape molecules; they also exhibit the bizarre effects associated with quantum mechanics. Scientists can exploit these characteristics to custom-build new materials “from the bottom up” with characteristics such as compatibility with living cells and the ability to turn light into tiny electrical currents that can produce responses in nerves.

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Nanotechnology in Aerospace

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