Researchers have created a molecular switch that can reversibly turn any mammalian gene on or off and control its level of expression. The results, published this week in Cell, provide a new level of precision in studying genes involved in biological processes and diseases, the authors say.
Copyright © 2007 Cell Press. All rights reserved.
Cell, Vol 130, 363-372, 27 July 2007
A Tunable Genetic Switch Based on RNAi and Repressor Proteins for Regulating Gene Expression in Mammalian Cells
Tara L. Deans,1 Charles R. Cantor,1 and James J. Collins1,